Etosif 120
Etosif-120 is a non-steroidal anti-inflammatory drug (NSAID) containing Etoricoxib 120 mg, used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis. It works by selectively inhibiting the COX-2 enzyme, reducing pain and swelling with fewer gastrointestinal side effects compared to other NSAIDs.
Etosif-120, with the active ingredient Etoricoxib 120 mg, is a selective COX-2 inhibitor belonging to the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is designed to alleviate pain, inflammation, and swelling in various musculoskeletal and joint disorders. By specifically targeting the cyclooxygenase-2 (COX-2) enzyme, Etosif-120 reduces the production of prostaglandins, which are chemical messengers responsible for pain and inflammation, while sparing COX-1, which helps protect the stomach lining. This makes it a preferred choice for patients who are prone to gastrointestinal issues with other NSAIDs like ibuprofen or naproxen. Etosif-120 is commonly prescribed for short-term relief of acute pain, such as in gout or post-dental surgery, and for chronic conditions like arthritis. The medication is available in tablet form and is typically taken once daily, with or without food, offering a rapid onset of action (within 25–30 minutes) and a long duration of effect (up to 24 hours) due to its 22-hour half-life. It is metabolized primarily by the liver via cytochrome P450 enzymes and excreted through urine, requiring caution in patients with liver or kidney impairments.
Key Benefits:
- Pain Relief: Effectively reduces moderate to severe pain in conditions like osteoarthritis, rheumatoid arthritis, and post-dental surgery pain.
- Anti-Inflammatory Action: Decreases inflammation and swelling in joints and muscles, improving mobility and quality of life.
- Gastrointestinal Safety: Causes fewer stomach-related side effects compared to traditional NSAIDs due to selective COX-2 inhibition.
- Rapid Onset and Long Duration: Provides quick pain relief (within 25–30 minutes) with a prolonged effect, allowing once-daily dosing.
- Versatility: Suitable for both acute pain (e.g., gout, dental surgery) and chronic conditions (e.g., arthritis).
Active Ingredients:
| Ingredient | Amount per Tablet |
|---|---|
| Etoricoxib | 120mg |
Recommended Uses:
Etosif-120 is indicated for:
- Osteoarthritis: To relieve pain and inflammation in degenerative joint disease.
- Rheumatoid Arthritis: To manage joint pain and swelling caused by autoimmune attack on tissues.
- Ankylosing Spondylitis: To reduce pain and stiffness in the spine and large joints.
- Acute Gouty Arthritis: For short-term relief of pain and inflammation due to uric acid crystal deposition.
- Postoperative Dental Pain: To alleviate moderate pain following dental procedures.
- Chronic Low Back Pain: For symptomatic relief in some cases, as prescribed.
Recommended Dosage:
Administration:
- Swallow the tablet whole with a glass of water. Do not crush, break, or chew unless specified.
- Take once daily, with or without food. Taking without food may enhance the speed of onset.
- Take as soon as remembered unless it is close to the next dose. Do not double the dose to compensate.
- Seek immediate medical attention if overdose symptoms like severe stomach pain, vomiting blood, or chest pain occur.
Common Side Effects:
Most side effects are mild and resolve over time. They include:
- Stomach pain or discomfort
- Nausea or vomiting
- Diarrhea or constipation
- Heartburn or indigestion (dyspepsia)
- Headache
- Dizziness or vertigo
- Fatigue
- Swelling of legs or ankles (edema)
- Increased blood pressure
- Palpitations
- Flu-like symptoms (fever, cold, cough)
- Mouth ulcers
- Gastritis or flatulence
Serious Side Effects (Seek Medical Attention Immediately):
Seek immediate medical attention if you experience:
- Cardiovascular Events: Chest pain, shortness of breath, or signs of heart attack/stroke.
- Gastrointestinal Issues: Severe stomach pain, black stools, or blood in vomit/stool indicating bleeding or ulcers.
- Allergic Reactions: Swelling of face/lips/tongue, difficulty breathing, or severe skin rash (e.g., Stevens-Johnson syndrome).
- Liver Dysfunction: Jaundice, dark urine, or persistent nausea.
- Kidney Problems: Reduced urine output, swelling due to fluid retention, or signs of nephrotoxicity.
- Hypersensitivity: Anaphylaxis or angioedema requiring urgent care.
Contraindications:
Do not use Etosif-120 if you have:
- Hypersensitivity to Etoricoxib or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe liver disease (e.g., cirrhosis) or kidney disease (e.g., severe renal impairment).
- Uncontrolled hypertension or significant cardiovascular disease (e.g., recent heart attack, stroke, or heart failure).
- History of bronchospasm, rhinitis, or urticaria associated with aspirin or other NSAIDs
- Pregnancy or breastfeeding (Category C; may cause fetal harm or pass into breast milk).
- Age under 16 years.
- Inflammatory bowel disease (e.g., Crohn’s disease, ulcerative colitis)
- Concurrent use with high-dose aspirin or other NSAIDs without medical supervision
Storage Conditions:
- Store at room temperature (20–25°C or 68–77°F).
- Keep in a dry, low-humidity area away from direct sunlight or heat.
- Keep out of reach of children
- Store in the original packaging to protect from moisture.
Shelf Life:
The shelf life of Etosif-120 is typically 2–3 years from the date of manufacture, as indicated on the packaging. Do not use after the expiry date (last day of the stated month). Always check the carton or blister pack for the exact expiry date.
Information provided is for educational purposes only. Always consult your healthcare provider before starting any medication. This product is available by prescription only in many countries. Follow your local regulations for proper acquisition and use of this medication.