Levoshe-M

Levoshe-M is an anti-allergic medication combining two active ingredients: Levocetirizine Dihydrochloride (2.5 mg per 5 ml), a second-generation antihistamine, and Montelukast Sodium (4 mg per 5 ml), a leukotriene receptor antagonist. This syrup is formulated to address allergic symptoms and respiratory issues, particularly in pediatric patients. Levocetirizine works by blocking histamine, a chemical responsible for allergy symptoms like sneezing, runny nose, and itchy eyes. Montelukast inhibits leukotrienes, which cause inflammation and constriction in the airways, thus aiding in asthma management and reducing nasal inflammation. Levoshe-M is commonly prescribed for children to manage seasonal or perennial allergic rhinitis, asthma, and chronic urticaria (hives). It is available as an oral syrup, making it easier for children to consume. The medication is typically taken in the evening to control symptoms overnight and during the day.

Key Benefits:

Levoshe-M provides a synergistic effect by targeting two pathways of allergic reactions:

• Allergy Symptom Relief: Reduces sneezing, runny or itchy nose, watery eyes, and skin itching caused by allergic rhinitis or hives.
• Asthma Management: Helps prevent asthma symptoms like wheezing and shortness of breath by reducing airway inflammation.
• Chronic Urticaria: Alleviates itching and swelling associated with chronic hives.
• Seasonal Allergies: Effective during pollen seasons to control hay fever symptoms.
• COPD Symptom Control: May relieve airway constriction in chronic obstructive pulmonary disease (COPD) in some cases. The combination simplifies treatment by addressing multiple symptoms with a single medication, improving patient compliance.

Active Ingredients:

Ingredient	Amount per Tablet	Function
Levocetirizine Dihydrochloride	2.5 mg per 5 ml	antihistamine
Montelukast Sodium	4 mg per 5 ml	leukotriene receptor antagonist

Recommended Uses:

Levoshe-M is indicated for:

• Allergic Rhinitis: Seasonal or perennial, to relieve symptoms like sneezing, runny nose, and itchy eyes.
• Asthma: Long-term management to reduce airway inflammation and prevent asthma attacks
• Chronic Urticaria: Treatment of hives causing itching and swelling.
• Seasonal Allergies: Management of symptoms triggered by pollen or other allergens
• Exercise-Induced Bronchoconstriction: Prophylaxis when taken before physical activity (as advised by a doctor).

Recommended Dosage:

Dosage depends on age, health condition, and doctor’s advice. Typical guidelines for Levoshe-M syrup:

Administration:

• Route: Oral, using the provided measuring cup for accurate dosing.
• Timing: Preferably in the evening to manage symptoms overnight.
• With/Without Food: Can be taken with or without food; food may delay absorption but does not affect efficacy.
• Instructions: Shake the bottle well before use. Swallow the syrup directly or mix with a small amount of water if needed. Do not crush or chew if in tablet form (not applicable for syrup).

Common Side Effects:

Most side effects are mild and resolve as the body adjusts:

• Drowsiness or sedation
• Dry mouth
• Headache
• Fatigue
• Nausea
• Diarrhea
• Vomiting
• Abdominal pain
• Skin rash
• Flu-like symptoms If side effects persist or worsen, consult a doctor. Drinking water may help with dry mouth.

Serious Side Effects (Seek Medical Attention Immediately):

Rare but serious side effects requiring immediate medical attention:

• Neuropsychiatric Effects: Anxiety, aggression, depression, suicidal thoughts, hallucinations, nightmares, or behavioral changes (especially with Montelukast; FDA Boxed Warning).
• Severe Allergic Reactions: Swelling, rash, or difficulty breathing.
• Urinary Retention: Difficulty urinating.
• Liver Issues: Hepatitis, jaundice, or elevated liver enzymes.
• Heart Issues: Rapid or irregular heartbeat, hypotension
• Heart Issues: Rapid or irregular heartbeat, hypotension
• Seizures or confusion.
• Skin Reactions: Acute generalized exanthematous pustulosis (rare). Parents should monitor children for mood or behavioral changes and report them immediately.

Contraindications:

Storage Conditions:

• Store at room temperature (15–25°C) in a dry place
• Keep away from direct heat and light
• Keep out of reach of children
• Do not use after the expiry date printed on the bottle.

Shelf Life:

The shelf life of Levoshe-M syrup is typically 2 years from the date of manufacture when stored under recommended conditions. Check the expiry date on the packaging and do not use if expired.